Instituto de Biología Funcional y Genómica
CSIC - University of Salamanca
Salamanca (Spain) June 4-5th, 2015

Scientific Program

Thursday, June 4th: The Biology of Meiosis

08:30 – 9:15Registration

09:15Welcome introduction

Juan Manuel Corchado
Research Vice-President University of Salamanca

José María Medina
Ramón Areces Foundation

Sergio Moreno
IBFG Director

Juan Luis Santos
Ignasi Roig
Pedro San-Segundo
Organizers of the symposium

Session 1.

Chair: Julie Cooper
National Cancer Institute, Bethesda, USA

09:30Different means to a common end
Denise Zickler (Université Paris-Sud, France)

10:00Genome-wide analysis of DNA end resection during yeast meiosis
Scott Keeney (Memorial Sloan Kettering Cancer Center, New York, USA)

10:30Genome location influences meiotic recombination biochemistry
Michael Lichten (National Cancer Institute, Bethesda, USA)

11:00Restriction of Topoisomerase II levels by Aminopeptidase P prevents genome instability
Enrique Martínez-Pérez (Medical Research Council, London, UK)

11:15 – 12:00Coffee break

Session 2.

Chair: Terry Hassold
Washington State University, Pullman, USA

12:00Crossing over: from models to crops
Chris Franklin (University of Birmingham, Birmingham, UK)

12:30Chromatin identity crisis: centromeres impersonating telomeres, in meiosis and mitosis
Julie Cooper (National Cancer Institute, Bethesda, USA)

13:00Regulation of chromosome synapsis: mechanistic insights from C. elegans
Monica Colaiacovo (Harvard Medical School, Boston, USA)

13:30Prophase pathway for removal of a meiosis-specific cohesin from arms of chromosomes during late prophase I of meiosis.
Akira Shinohara (Osaka University, Osaka, Japan)

13:45 – 16:45Poster session and informal lunch

Session 3

Chair: Eva Hoffmann
University of Sussex, Falmer, UK

16:45Transcription dynamically patterns the meiotic chromosome-axis interface
Andreas Hochwagen (New York University, New York, USA)

17:15Meiotic checkpoint control of chromosome dynamics
Pedro San-Segundo (Instituto de Biología Funcional y Genómica, CSIC-USAL, Salamanca, Spain)

17:30ATR is required to complete meiotic recombination and chromosome synapsis in mice
Ignasi Roig (Universidad Autónoma de Barcelona, Spain)

17:45Cdc14b regulates the pachytene checkpoint in mammals
Marcos Malumbres (Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain)

18:00-18:30Coffee break

18:30Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program
José Ayté (Universidad Pompeu Fabra, Barcelona, Spain)

18:45Isolation and characterization of the clt-2 mutant and its interactions with the FA/BRC recombination pathway in Caenorhabditis elegans
Pamela Santonicola (CNR Institute of Biosciences and Bioresources, Napoli, Italy)

19:00Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM
Mathilde Seguela-Arnaud (Institut Jean-Pierre Bourgin, Versailles, France)

19:15CEP63 controls centriole duplication during prophase I and is required for meiotic recombination and male fertility
Travis Stracker (Institute for Research in Biomedicine (IRB), Barcelona, Spain)

19:30Histone H2AX phosphorylation modulates the choice of DSB processing pathway during plant meiosis
Eugenio Sánchez-Morán (University of Birmingham, Birmingham, UK)

Friday, June 5th: : Chromosome missegregation and meiotic disorders

Session 4

Chair: Scott Keeney
Memorial Sloan Kettering Cancer Center, New York, USA

09:00Exploring the role of replicative stress in cancer and ageing
Óscar Fernández-Capetillo (CNIO, Madrid, Spain)

09:30How oocytes try to get it right: spindle checkpoint control in meiosis
Katja Wassmann (University of Paris, France)

10:00STAG2 subunit of the cohesin complex is essential for the completion of meiosis in the mouse
Alberto Pendás (Centro de Investigación del Cáncer, CSIC-USAL, Salamanca, Spain)

10:30Sex-specific differences in human meiosis
Terry Hassold (Washington State University, Pullman, USA)

11:15Sex-specific variation in genome-wide recombination rate is controlled by Meiotic recombination 1 within Hybrid sterility X2 locus
Jiri Forejt (Institute of Molecular Genetics, Prague, Czech Republic)

11:15 – 12:00Coffee break

Session 5

Chair: Michael Lichten
National Cancer Institute, Bethesda, USA

12:00MeioMaps from oocytes and embryos reveal novel features of recombination and chromosome segregation in human female meiosis with implications for human age-related aneuploidy
Eva Hoffmann (University of Sussex, Falmer, UK)

12:30Chromosome missegregation in meiosis and embryo aneuploidy: preimplantation chromosome screening
Xavier Vendrell (Sistemas Genómicos, Valencia, Spain)

13:00Molecular mechanisms regulating meiosis in the male: perspective on human spermatogenic failure
Sara Larriba (IDIBELL, Barcelona, Spain)

13:30Reproductive effects of double stranded sperm DNA breaks: recurrent miscarriage and implantation failures
Jordi Ribas-Maynou (Centro de Infertilidad Masculina y Análisis de Barcelona (Cimab), UAB, Barcelona, Spain)

13:45Altered bivalent positioning in metaphase I human spermatocytes from Robertsonian translocation carriers
Zaida Sarrate (Universidad Autónoma de Barcelona, Spain)

14:00Closing Remarks


16:00Local meeting of the Spanish Meiosis Network

17:30Guided cultural visit to Monumental Salamanca

Scientific Program

VIII Centenario de la Universidad de SalamancaUniversidad de SalamancaCSICIBFGFundación Areces